An in vivo study has suggested that curcumin mediates the infiltration of fibroblasts into wound sites, which in turn naturally differentiates into myofibroblasts during the formation of granulation tissue [82]. Expression of hepatic antioxidant genes in l-thyroxine-induced hyperthyroid rats: Regulation by vitamin E and curcumin. Reichrath J., Lehmann B., Carlberg C., Varani J., Zouboulis C.C. Given that protein-calorie deficiencies are further associated with weight loss and decreased lean body mass [27], their implications for wound patients should be also recognized. Woo J.H., Kim Y.H., Choi Y.J., Kim D.G., Lee K.S., Bae J.H., Min D.S., Chang J.S., Jeong Y.J., Lee Y.H., et al. Hunt T.K., Ehrlich H.P., Garcia J.A., Dunphy J.E. Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1. For instance, vitamin C seems to act only in combination with zinc and arginine [51], while vitamin E appears to counteract the benefits of vitamin A [56]. When annual productivity was compared, most countries/regions showed a positive surge in interest in the research field, for example, in India, USA, and China. Topics shown in blue were prevalent at the beginning of the year 2000, green topics were more prevalent between 2015 and 2018, and yellow topics predominated in the years following 2018. Lansdown A.B., Mirastschijski U., Stubbs N., Scanlon E., Agren M.S. Beyond that, fibrin plug also provides an extracellular matrix for cell migration [2] and releases growth factors (e.g., platelet-derived growth factorPDGFand transforming growth factorTGF) involved in the recruitment of cells to the wound [1,2]. Albina J.E., Gladden P., Walsh W.R. Here, we discovered that over 98 countries have made contributions to the field and the number of papers devoted to this topic is increasing every year. Cutaneous wound healing: recruiting developmental pathways for regeneration. Proteins are also necessary for immune response, which in turn, if impaired, may delay the progression from the inflammatory to the proliferative phase. The recent literatures on the wound healing properties of curcumin also provide evidence for its ability to enhance granulation tissue formation, collagen deposition, tissue remodelling and. Table 2 shows the top 10 countries measured by article count, among which India ranked first, followed by China, USA, Iran, and Italy. A concept analysis of malnutrition in the elderly. Bethesda, MD 20894, Web Policies The identified publications that mentioned the word curcumin or turmeric or curcuma spp. and wound in the title, abstract, or keywords were selected for the bibliometric review analysis. To date, the effect of supplementation of essential fatty acids on wound healing is controversial. A previous study has also demonstrated that curcumin reduces the epithelialization period of treated wounds if compared with the control group [70]. Mats J.M., Segura J.A., Alonso F.J., Mrquez J. Blass S.C., Goost H., Tolba R.H., Stoffel-Wagner B., Kabir K., Burger C., Stehle P., Ellinger S. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT. First, the PCEC polymer was used as a carrier to deliver curcumin by forming curcumin nanoparticles. Curcumin as a wound healing agent. ; data curation: F.F. Among these, thiamine, riboflavin, pyridoxine and cobalamins are also required for the synthesis of collagen [25]. Federal government websites often end in .gov or .mil. Physiologically, wound healing consists of three phases: Inflammation, proliferation, and remodeling or maturation [3]. Falanga V. Wound healing and its impairment in the diabetic foot. Topman G., Lin F.H., Gefen A. In line with this evidence, the co-supplementation of omega-3 and omega-6 might lead to benefits, especially during the inflammatory phase [33]. in HCT116 p53-deficient cells by MTT assay after transfection NRF2 siRNA pool or control siRNA pool 24 hours with curcumin for 48 hours. During collagen synthesis, vitamin C forms extra-bounds between collagen fibers that increase stability and strength of collagen matrix [8]. Falanga V. The chronic wound: Impaired healing and solutions in the context of wound bed preparation. official website and that any information you provide is encrypted the contents by NLM or the National Institutes of Health. A total of 5503 authors contributed to the 1284 articles. We have summarized that protein loss may negatively affect the whole immune process, while adequate intake of carbohydrates is necessary for fibroblast migration during the proliferative phase. Nutrition and wound healing. Akbik D., Ghadiri M., Chrzanowski W., Rohanizadeh R. Curcumin as a wound healing agent. The size of the circle is directly related to the documents that each country generated, and the fine lines demonstrate the collaboration strength. In wound patients, it has been recommended to have a short-term supplementation of 10,00025,000 IU/day to avoid toxicity [33]. MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. The results collected can serve as a guide for those wanting to make contributions to this field by providing details about active journals, authors, and widely researched topics in this area. Wicke C., Halliday B., Allen D., Roche N.S., Scheuenstuhl H., Spencer M.M., Roberts A.B., Hunt T.K. Breslow R.A., Hallfrisch J., Guy D.G., Crawley B., Goldberg A.P. The rapid growth in publications from 1942 to 2021 is obvious from the diagram, and a trend analysis of the annually generated corpus from the top 3 contributing countriesIndia, China, and the United Statesis more interesting. Williams J.Z., Barbul A. Mohanty C., Das M., Sahoo S.K. It has a long history of use in medicine, with the earliest known evidence dating back 6000 years [7]. Apoptosis down-regulates inflammation under the advancing epithelial wound edge: Delayed patterns in diabetes and improvement with topical growth factors. Wound healing implicates several biological and molecular events, such as coagulation, inflammation, migration-proliferation, and remodeling. The first one was published in 1942. Turmeric ( Curcuma longa, diabetic ulcers, anorexia, cough and sinusitis. Curcumin prevents maleate-induced nephrotoxicity: Relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Zheng Q.T., Yang Z.H., Yu L.Y., Ren Y.Y., Huang Q.X., Liu Q., Ma X.Y., Chen Z.K., Wang Z.B., Zheng X. Synthesis and antioxidant activity of curcumin analogs. An official website of the United States government. Topical formulations of curcumin provide better delivery at wounded sites. Background: Curcumin has been widely used to treat a variety of diseases and disorders since ancient times, most notably for the purpose of healing wounds. India outpaces the US in terms of article production, reaching up to 55 articles annually compared to the USs maximum of 22. Nutrition for optimum wound healing. Scope and approach: To evaluate the influence and significance of the countries, journals, organizations and authors that have contributed the most to this topic, the popular bibliometric markers, including article count, citation count, and Hirsch index (H-index), are taken into account. When the co-occurrence analysis of the authors keyword was conducted, a total of 3143 keywords appeared (Figure 7). Kant V., Gopal A., Kumar D., Pathak N.N., Ram M., Jangir B.L., Tandan S.K. The anti-inflammatory effects of curcumin are also involved in other signaling pathways, such as peroxisome proliferator-activated receptor-gamma (PPAR-) and myeloid differentiation protein 2-TLR 4 co-receptor (TLR4-MD2) [65,66,67,68]. This has led to widespread use of numerous plants and their derivatives in the Asian and African subcontinents. Although curcumin could be considered as a wound healing agent, especially if topically administered, further research in wound patients is recommended to achieve appropriate nutritional approaches for wound management. The United States has a greater academic influence than the rest of the world, as evidenced by the highest number of citations (13,361), despite the fact that India provided the most articles (354 articles), accounting for more than 27.49 percent of the total corpus pertaining to curcumin and wound healing. Vitamin A deficiency impairs B cell and T cell function and antibody production during the inflammatory phase. Background: Curcumin has been widely used to treat a variety of diseases and disorders since ancient times, most notably for the purpose of healing wounds. By identifying key contributors and outlining the scientific collaborations, the results represent a broad overview of the literature already available. Finally, once closure of the wound has been achieved, apoptotic processes discard inflammatory cells from wound sites [88,89,90]. Dermal wound healing is subject to redox control. Theilla M., Schwartz B., Cohen J., Shapiro H., Anbar R., Singer P. Impact of a nutritional formula enriched in fish oil and micronutrients on pressure ulcers in critical care patients. In addition, curcumin appears to be beneficial for epithelialization [70] and for apoptotic processes that discard inflammatory cells from the wound site [88,89,90]. In fact, curcumin was commonly used in traditional medicine for the treatment of biliary and hepatic disorders, cough, diabetic ulcers, rheumatism and sinusitis [11]. The co-occurrence of total keywords, authors keywords and co-authorship analysis was performed by using the full counting method showing only the elements connected with each other. Based on the pattern of development observed, we can infer that curcumin research in wound healing and its application will continue to garner more and more attention in academia in the near future. To the best of our knowledge, this is the first bibliometric review on the topic and hence it is envisaged that it will attract researchers to explore future research dimensions in the related field. Due to the relatively low level of collaboration across these institutes, initiatives to build deeper links may help this field advance in the future. Treatment of a chronic hard-to-heal wound and its therapeutic impediments have always attracted great concern in health care and medical fields, bringing about substantial economically challenging burdens worldwide (1-5). Here, we provide an overview of the effects of malnutrition and specific nutrients on this process, focusing on the beneficial effects of curcumin. For instance, it has been demonstrated that omega-6 supplementation decreases the progression of pressure ulcers [32], and its combination with omega-3 has beneficial effects on the inflammatory phase [33]. To solve the question of whether curcumin is a suitable wound healing agent, we have summarized its biochemical and molecular effects during the different phases of wound healing, as well as evidence from epidemiological studies. KEYWORDS curcumin, electrospinning, nanofiber, wound healing 1 INTRODUCTION The turmeric plant belongs to the ginger family and has been used for The use of natural products against sickness and affliction has only recently caught the attention of the scientific community, despite the fact that many plant-derived compounds have been utilized for the treatment of various ailments since antiquity. (a). the depth dimension. Ravindranath V., Chandrasekhara N. Absorption and tissue distribution of curcumin in rats. Vitamins are undoubtedly the most investigated micronutrients in the wound healing process. The font size of the words on the bubble map represents how frequently the terms occur (multiple appearances in a single publication count as one). In the proliferative and remodeling phases, protein-energy deficiency may also decrease fibroblast activity, delaying angiogenesis and reducing collagen formation [8]. Alven S., Nqoro X., Aderibigbe B.A. The https:// ensures that you are connecting to the A wound is a physical disruption of the skin architecture due to trauma resulting in fluid loss, injury and pain to the individual [].Wounds are classified as chronic and acute wounds based on their duration and the nature of the healing process [].Chronic wounds are injuries that fail to heal via the normal wound healing process . When we decided whether an article should be included, we first considered its relevance to curcumin as a wound-healing agent. In the first phase after injury, the formation of a fibrin plug (i.e., an aggregate of platelets, fibrinogen, fibronectin, vitronectin, and thrombospondin) is necessary both for hemostasis and for covering and protecting the wound from bacteria [2,16]. Akbik D., Ghadiri M., Chrzanowski W., Rohanizadeh R. Curcumin as a wound healing agent. Salehi B., Rodrigues C.F., Peron G., DallAcqua S., Sharifi-Rad J., Azmi L., Shukla I., Singh Baghel U., Prakash Mishra A., Elissawy A.M., et al. Citations of these articles collected up to January 2022 were considered. Todorovic V. Food and wounds: Nutritional factors in wound formation and healing. Accessibility The best network for collaboration, meanwhile, only includes Iranian institutions. In fact, fibroblast migration depends on several factors that cannot be entirely mimicked with in vitro models, such as cell-environment interactions and homeostatic mechanisms [17]. Curcumin nano formulations for microbial and wound healing purposes. Evans C. Malnutrition in the elderly: A multifactorial failure to thrive. In wounds, it protects against the risk of infectious and inflammatory complications by up-regulating the expression of heat shock proteins [40]. Up until 2005, India and the USA had a slow rise, but after that, a significant increase in publication was noted. The site is secure. Moral-Muoz J.A., Herrera-Viedma E., Santisteban-Espejo A., Cobo M.J. Software tools for conducting bibliometric analysis in science: An up-to-date review. The Cellular and Molecular Research Center of Iran University of Medical Sciences is the most collaborative, with 8 different collaborators followed by Biotechnology Research Center (5), Neurogenic Inflammation Research Center (5) and School of Pharmacy (5). The recent research has been more focused on drug delivery systems using modern biotechnological techniques to enhance the specificity of the curcumin molecule toward the drug target. The .gov means its official. HHS Vulnerability Disclosure, Help Curcumin-induced angiogenesis hastens wound healing in diabetic rats. Wound healing implicates a well-orchestrated complex of biological and molecular events that involve cell migration, cell proliferation, and extracellular matrix deposition. Malnutrition. Licensee MDPI, Basel, Switzerland. We fabricated a PVA/collagen composite film containing Cur/PCEC nanoparticles for promoting wound healing as indicated in Scheme 1. Sidhu G.S., Singh A.K., Thaloor D., Banaudha K.K., Patnaik G.K., Srimal R.C., Maheshwari R.K. Enhancement of wound healing by curcumin in animals. More international cooperation would enhance information exchange and promote development in this area of study. Inflammation is important in fighting against infections. Sidhu G.S., Mani H., Gaddipati J.P., Singh A.K., Seth P., Banaudha K.K., Patnaik G.K., Maheshwari R.K. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Vitamin D deficiency in patients with chronic venous ulcers. Moreover, prolonged high ROS concentrations are dangerous for cell structures leading to oxidative stress [70,71]. Received 2022 Dec 14; Revised 2022 Dec 28; Accepted 2022 Dec 28. Then the Cur/PCEC nanoparticles were incorporated with collagen and PVA to build a composite film used as a wound . Hence, implications of weight loss and decreased lean body mass should be recognized when considering the effect of protein-calorie deficiency on the healing process. Different visualization maps representing the collaboration network of authors, nations, and organizations were created where larger circles indicate more collaborations and stronger links between those who collaborate more frequently. and transmitted securely. Wei Y., Yuan X., Wu G., Yang L. Climate change risk assessment: A bibliometric analysis based on web of science. Kirk S.J., Hurson M., Regan M.C., Holt D.R., Wasserkrug H.L., Barbul A. Arginine stimulates wound healing and immune function in elderly human beings. Beyond proteins, both carbohydrates and fats address increased energy needs to support inflammatory response, cellular activity, angiogenesis, and collagen deposition in the proliferative phase of healing process [26]. Glutamine is also a precursor of glutathionean antioxidant and an essential cofactor of several enzymatic reactionswhich is important for stabilizing cell membranes and for transporting amino acids across them [41]. Chiari W., Damayanti R., Harapan H., Puspita K., Saiful S., Rahmi R., Rizki D.R., Iqhrammullah M. Trend of Polymer Research Related to COVID-19 Pandemic: Bibliometric Analysis. Glutamine and glucose metabolism in human peripheral lymphocytes. Our review summarizes current evidence about the main biochemical and molecular effects of nutrition, in terms of quality and quantity, on the wound healing process.
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