Pellegrini M., Senni C., Bernabei F., Cicero A.F.G., Vagge A., Maestri A., Scorcia V., Giannaccare G. The role of nutrition and nutritional supplements in ocular surface diseases. Inflammation and oxidative stress act as components of a double-ended relationship. De la Fuente M. Effects of antioxidants on immune system ageing. Cicero A.F., Colletti A. In addition, enhanced apoptosis was detected in all the groups with elevated IOP in contrast to that one treated with astaxanthin, which showed a significant reduction of apoptotic cells percentage. Comparisons of vision formulas in eye health supplements to the clinically studied AREDS and AREDS2 formulations, including our assessments of products not tested in this review: Ocuvite, Lipotriad, MacuHealth with LMZ3, 4Sight, OcuGard Plus, and Nutrilite Vision Health with Lutein. In this regard, Lin and coauthors investigated the effect of astaxanthin administration in an experimental rat model of NAION and showed that this carotenoid was able to preserve visual function and reduce apoptosis of retinal ganglion cells after ischemic insult. The majority of these conditions are characterized by oxidative stress, ischemia and apoptosis as the main pathogenic factors [16,26,31,32,33,34]. The tricky part is that meso-zeaxanthin is not in the normal dietit's found in shrimp shells, fish skin, and turtle shells," Anshel says, explaining the need for adequate lutein (and zeaxanthin) through diet and supplementation to make sure you get enough of these essential macular carotenoids. There are a number of nutrients that support eye health and longevity, and most of them aren't vitamins at all. 2009 - 2023 mindbodygreen LLC. FOIA If you're looking for an eye supplement that can sweeten your day, this strawberry-flavored gummy is for you! Proper blood flow and blood vessel integrity are critical for getting our eyes the nutrients they need, when they need them. Astaxanthin (3,3-dihydroxy-,-carotene4,4-dione; molar mass 596.84 g/mol) is a naturally occurring carotenoid whose structural and functional characteristics make it a promising bioactive compound in the prevention of several human diseases as well as in the maintenance of a good health status [1]. Relevant articles published to March 2020 were searched using PubMed, Scopus and Medline databases, as well as through the reference lists of identified publications. Astaxanthin For Glaucoma 7. Yuan J.P., Peng J., Yin K., Wang J.H. It protects the eyes from dangerous free radicals, unstable molecules that steal electrons from healthy cells, causing damage (what's known as oxidation). Astaxanthin, a carotenoid found in Haematococcus pluvialis may be small, but it is mighty! The supplementation period lasted 8 weeks and patients were followed up every 4 weeks for 16 weeks. When compared to controls, elevated IOP increased retinal protein oxidation, which returned to baseline levels in the group treated with astaxanthin. Effects of astaxanthin on oxidative stress in overweight and obese adults. Sports Research Triple Strength Astaxanthin, Life Extension Tear Support with MaquiBright, Higher price point (due to comprehensive formula), Offered in formulas with and without zinc, No artificial colors, flavors, or sweeteners. With 60 milligrams of maqui berry extract, this highly potent supplement helps aid eye lubrication from the inside out to support overall eye comfort and ease while wearing contacts, using a computer, or dealing with other environmental factors that can contribute to occasional eye dryness.*. writingoriginal draft preparation, all the authors; writingreview and editing, G.G. It can assist your body's recovery process after exercise and muscle damage and is even known to help optimize strength and endurance. 9. . mindbodygreen ultimate multivitamin+ Go to review Best for dry eye support Life Extension Tear Support with MaquiBright Go to review Best for eye blood vessel support Thorne O.P.C.-100 Go to review Best botanical eye blend Pure Synergy Eye Protector Go to review Best AREDS-inspired formula Pure Encapsulations EyeProtect Basics Go to review Instead, astaxanthin is primarily found in wild salmon," Hecht explains. Fakhri S., Abbaszadeh F., Dargahi L., Jorjani M. Astaxanthin: A mechanistic review on its biological activities and health benefits. Protects against UV rays: It's worth mentioning astaxanthin's natural knack for protecting our skin against damaging UV rays when ingested or used topically. A wide spectrum of properties including anti-inflammatory and antioxidant activities as well as metabolism regulation make astaxanthin a suitable multitarget pharmacological agent. While these essential nutrients provide daily foundational nutrition support for women and men, a comprehensive eye supplement like mbgs eye health+ that includes targeted visual performance plant bioactives via high-potency carotenoids, maqui berry, and saffron can take your vision support to the next level. Astaxanthin is a prized antioxidant supplement, it offers a range of distinct health benefits, including eye health. the contents by NLM or the National Institutes of Health. Yang C.H., Albietz J., Harkin D.G., Kimlin M.G., Schmid K.L. In particular, a prospective randomized double-blinded study was performed to compare the effects of an antioxidant supplement containing anthocyanosides, astaxanthin, vitamins A, C, E, and several herbal extracts (including Cassiae semen and Ophiopogonis japonicus) with placebo in patients suffering from dry eye disease. "If skin, hair and nail health are your primary concerns, Hunter & Gather also makes marine collagen . An Italian multicentre observational study. Why? We chose supplements from brands that prioritize analytical quality testing to ensure the purity and potency of each product in their portfolio. Effects of Carotenoids on Health: Are All the Same? All authors have read and agreed to the published version of the manuscript. In this regard, astaxanthin has gained growing interest as a multitarget pharmacological agent against neurodegenerative disorders including Parkinsons disease, Alzheimers disease, brain and spinal cord injuries and neuropathic pain, due to its antioxidative, anti-inflammatory and antiapoptotic properties [2]. Careers, Unable to load your collection due to an error. Benefits of Astaxanthin. Retinal ganglion cell death is a common feature of many retinal disorders such as glaucoma, optic neuropathies and diabetic retinopathy, whereas RPE cells death plays a key role in AMD pathogenesis. Izumi-Nagai K., Nagai N., Ohgami K., Satofuka S., Ozawa Y., Tsubota K., Ohno S., Oike Y., Ishida S. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Teaser: If you want to support your best health from your head to your toes, it might be time to add astaxanthin to your supplement routine. These oxidative products in turn enhance the inflammatory cascade by means of NF-B activation and together alter cellular and molecular targets, destroying normal tissue homeostasis [51,52]. "Eyes are exposed to physiological and environmental factors that trigger free radical production. The problem? Many of the most famous vision supplements include multiple synthetic dyes, opacity agents (e.g., titanium dioxide), corn syrup, and other low-quality ingredients. Be sure to consult with your doctor first before taking any . from light (indoor and outdoor), pollutants, air temperature, and more. 500 milligrams vitamin C. 400 IU vitamin E. 2 milligrams copper. Pellegrini M., Giannaccare G., Bernabei F., Moscardelli F., Schiavi C., Campos E.C. Both these conditions cause eye vulnerability to irradiation-initiated oxidative damage and subsequent inflammation. Maqui berries have been clinically shown to promote tear production and enhance overall eye hydration. Like all gummy supplements, the list of "other" ingredients is long here but relatively clean. Bilberry Extract Saffron Astaxanthin A Multivitamin Taking these eye nutrients together in a stack creates nutritional synergy and boosts visual performance from many angles. Age-related macular degeneration is a leading cause of vision loss among adult individuals in developed countries and occurs due to photoreceptor degeneration in the macula, which is responsible for sharp and high-resolution vision. Utilize this guide to find an eye supplement that supports your eyes' daily needs and promotes vision longevity later in life.*. But vision-critical carotenoids don't end with lutein, zeaxanthin, and meso-zeaxanthin. For example, the foundational eye health ingredients we intentionally and comprehensively feature in mbgs ultimate multivitamin+ include vitamin A (in beta-carotene and retinol formats), vitamin C, vitamin E, riboflavin, zinc, copper, and even lutein and zeaxanthin (this is unique for a multivitamin).*. Cataract development causes the opacity of the natural lens of the eye, thus leading to decreased visual acuity. For a holistic daily multivitamin that specifically targets eye health and supports visual performance, this multi can't be beat! Search terms included the following key phrases: astaxanthin; carotenoids; eye; age-related macular degeneration; glaucoma; cataract; dry eye disease; oxidative stress; nutritional supplements. Age-related macular degeneration: Etiology, pathogenesis, and therapeutic strategies. All of these are majorly underconsumed in the U.S. At the end of the experimental period, neuroprotective effect of astaxanthin was determined via electrophysiological measurements of visual evoked potentials (VEP) together with the assessment of retinal apoptosis and oxidative markers expression. Product Details Vitamin A, vitamin C, and vitamin E Zinc Eyebright Lutein Astaxanthin, zeaxanthin, and meso-zeaxanthin macular supplement Phospholipids and marigold extract Bilberry fruit extract Saffron Omega-3 Based on the AREDS 2 formula Vegan Non-GMO, soy-free, gluten-free 2-month supply Manufactured in a cGMP-certified facility in the USA Thus, the aforementioned mechanisms of cellular death modulation may actively contribute to the amelioration of early brain injury as well as the reduction of retinal ganglion cell loss in a mice model of subarachnoid hemorrhage and diabetic retinopathy, respectively [26,30]. Check Lowest Prices. In agreement with the aforementioned neuroprotective effects of such xanthophyll carotenoid, the potential use of astaxanthin in the setting of nonarteritic anterior ischemic optic neuropathy (NAION), which is the most common cause of acute ischemic vision loss in people aged over 50 [49] has recently been suggested. Overall, these findings support the need for the development of neuroprotective therapies for glaucoma. *, In addition to all the essential vitamins and minerals you need for whole-body health, our multi delivers a plethora of vitamins, minerals, and botanicals that promote eye function and vision longevity: Vitamins A, C, and E deliver potent antioxidant actions that fight free radicals in the eye and support overall ocular health and function; trace minerals zinc and copper promote retinal function; and longevity phytonutrients lutein, zeaxanthin, and lycopene (which are innovative and unique additions to a multi) help combat oxidative stress in the eye and throughout the body. That said, we do suggest taking your daily eye supplement with a meal or soon after (i.e., within 30 minutes of a meal). As mentioned above, inflammation and oxidative stress are strongly associated and synergistically act as main pathogenic factors of ocular surface disorders [59]. Otsuka T., Shimazawa M., Inoue Y., Nakano Y., Ojino K., Izawa H., Tsuruma K., Ishibashi T., Hara H. Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. Asthenopia, otherwise called eye fatigue, is a common condition occurring on a daily cycle that presents with nonspecific symptoms including discomfort, lacrimation, blurry vision, light sensitivity and in more severe cases, pain. Your eyes are critical and metabolically active organs that require daily support from nutrients and phytonutrients that promote antioxidant protection, blue light filtering, ocular blood flow, lubrication, visual acuity, and more. This AREDS-inspired formula contains all of these critical nutrients (i.e., vitamins C and E, zinc, copper, lutein, and zeaxanthin) in efficacious doses and optimally bioavailable forms (per AREDS) to support eye integrity and help maintain the health and function of the retina and macula.*. Antioxidant activities of astaxanthin and related carotenoids. Kaur A., Gupta V., Christopher A.F., Malik M.A., Bansal P. Nutraceuticals in prevention of cataractAn evidence based approach. This array of vision longevity botanicals is rounded out by supporting players Patagonian maqui berry (to promote eye hydration and fight against dryness caused by excessive screen time) and saffron (to support photoreceptor cells and reduce eye pressure) for a truly comprehensive formula that will support your eyes today, tomorrow, and way down the road.*. Macular degeneration gradually leads to vision loss and subsequently significantly affects patients quality of life and daily productivity. This guide discusses how each of these eye supplements can work to both optimize your vision and support your long-range eye health. ); ti.orebil@aicrocsv (V.S. Even if you have 20/20 vision without wearing any type of corrective lenses, the ability to read highway signs isn't the single factor defining how well you care for your eyes. Application fields of astaxanthin range from the food-coloring industry, for its natural intense red color brightness, to aquaculture and poultry industries for its natural feed addictive properties [3]. Astaxanthin is one of the most powerful antioxidants in nature, making it an excellent supplement for combating oxidative stress and . Results showed that oral micronutrients supplementation significantly improved tear production and stability while decreased corneal fluorescein staining and tear ROS levels, thus leading to a significant amelioration in both signs and symptoms [65]. Giannaccare G., Pellegrini M., Sebastiani S., Bernabei F., Roda M., Taroni L., Versura P., Campos E.C. Key Nutrients to Support Eye Health & Healthy Vision. Photoreceptors are exposed to extensive oxidative stress in the form of light and oxygen, so that the outer 10% of photoreceptor segments are shed daily [35]. Oral supplementation of astaxanthin was shown to improve the symptoms and signs of middle-aged and elderly patients with mild-to-moderate dry eye disease (DED) in China. Astaxanthin might relieve eyestrain in people using computer monitors as suggested by Nagaki and coauthors, who conducted a double-blind randomized clinical trial by enrolling visual display terminal workers and prescribed them astaxanthin or placebo. Repairs DNA damage: The fact that it protects against UV rays is actually a two-fold benefit, as sun damage causes DNA damage. Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells. botanically derived carotenoids (e.g., lutein, zeaxanthin, lycopene, and astaxanthin), flavonoids (e.g., elderberry, bilberry, and grapeseed), and enzymes (e.g., kale, watercress, and SOD) that support the health and longevity of the retina, cornea, and eye blood vessels. Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data. ; literature search, all the authors; G.G. Zhang L., Wang H. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. 4. Potential clinical applications of such nutrients are discussed below. In particular, it has been shown to enhance the phosphorylation of BAD, the downregulation of cytochrome c, and the activation of caspases 3 and 9 through the regulation of mitogen-activated protein kinase/p38 (p38 MAPK), as well as the stimulation of the PI3K/AKT survival pathway, which in turn lead to the reduction of mitochondrial-related apoptosis [5,26,28,29]. RELATED: How To Use Lutein For Eyes Through Diet & Supplementation. National Library of Medicine ii On top of this, an additional study involving 49 healthy volunteers found that those taking 4mg or 12mg of astaxanthin a. The site is secure. Provides comprehensive ocular nutrition in a single softgel. Codeage Eye Vitamins is a comprehensive macular support supplement containing bioavailable astaxanthin. While salmon, shrimp, lobster and other astaxanthin-rich foods are delicious and healthy, eating them . Well, nutrients and oxygen are transported throughout the body via blood vesselsincluding those that make their way to the eye. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Akt/bad signaling. Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis. Interestingly, mice were daily supplemented with astaxanthin (100 mg/kg/day) either before or after inducing oxidative stress in the retina by photodynamic treatment. Your body should be approached with great care (especially your eyes). It might be useful as a treatment for. Recent findings of increased plasma levels of oxidative markers in NAION patients suggest the key role of oxidative processes in the pathogenesis of disturbed small-vessel autoregulation in posterior ciliary circulation, which then leads to vascular insufficiency and subsequent optic nerve head ischemia [50]. * However, it might be time to add another antioxidant to the list. . When compared to placebo group, treated patients showed selective improvement of central retina function, where carotenoids are naturally much more represented as endogenous pigments [40]. "Diet is a key lifestyle factor that can have long-term effects on ocular health. Ambati J., Ambati B.K., Yoo S.H., Ianchulev S., Adamis A.P. Suppressive effects of astaxanthin on glaucomatous retinal injury were assessed by Cort and coauthors, who conducted an experimental study on mouse models in which elevated IOP was induced by unilaterally cauterizing episcleral vessels. Your daily must-have essential for brain health and eye function, this omega-3 supplement delivers critical neuroprotective fatty acids EPA and DHA to promote eye integrity, visual acuity, retinal and macular health, and overall ocular function. Bethesda, MD 20894, Web Policies McNulty H., Jacob R.F., Mason R.P. DHA is a major structural lipid that makes up the outer segment membranes of the retinal photoreceptor cells and supports faster response to stimulation and optimal visual sensation to literally help us see clearly! This high-potency astaxanthin supplement delivers 12 milligrams of sustainably sourced Icelandic astaxanthin with organic virgin coconut oil (for enhanced absorption) in just one daily softgel. Grattagliano I., Palmieri V.O., Portincasa P., Moschetta A., Palasciano G. Oxidative stress-induced risk factors associated with the metabolic syndrome: A unifying hypothesis. Choroidal Vascular Changes in Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy. Lutein, Zeaxanthin, Astaxanthin, Bilberry, Elderberry, Green Tea, Grape Seed, Bioflavonoids. Before It remains one of the main causes of blindness worldwide and surgery is required to restore vision [55]. "Lutein is converted to another form [of zeaxanthin] called meso-zeaxanthin. Guo S.X., Zhou H.L., Huang C.L., You C.G., Fang Q., Wu P., Wang X.G., Han C.M. A growing body of evidence suggests that astaxanthin is efficacious in the prevention and treatment of several ocular diseases, ranging from the anterior to the posterior pole of the eye. Apoptosis is a form of programmed cell death with a crucial role in mammalian development and tissue homeostasis. Reason being: Many of the eye supplements on this list are chock full of carotenoids (including astaxanthin, lutein, zeaxanthin, and saffron crocins and crocetins), which are fat-soluble phytonutrient compounds by nature. As astaxanthin efficiently prevents ROS formation and exerts high scavenging activity towards hydroxyl radicals, treatment with this xanthophyll micronutrient is expected to halt both the onset and the progression of ROS-related diseases, as demonstrated by the reduced death of retinal ganglion cells and increased stability of the ocular surface unit. Skeletal structure of astaxanthin that consists of a ,-carotene-4,4-dione bearing two hydroxy substituents at positions 3 and 3. She received her bachelor's degree in Biological Basis of Behavior from the University of Pennsylvania and Ph.D. in Foods and Nutrition from the University of Georgia. The thing is, like all dietary supplements, finding an effective, high-quality eye supplement can be difficult (to say the least). More specifically, the American Optometric Associationas well as scientists from the academic domainhave clearly acknowledged the role of key nutrients in supporting eye health and vision performance," explains Deshanie Rai, Ph.D., FACN, vice president of scientific & regulatory affairs at OmniActive Health Technologies. Thanks to the digital stressors of modern life, our eyes need extra attention now more than ever. A growing body of evidence suggests that astaxanthin is efficacious in the prevention and treatment of several ocular diseases, ranging from the anterior to the posterior pole of the eye. Astaxanthin For Double Vision 5. Kim J.H., Chang M.J., Choi H.D. This makes them highly susceptible to oxidative stress (via toxins, free radicals, etc.) 2 milligrams zeaxanthin. Each double polyene bond can exist either as cis- or trans-geometric isomers. Inflammatory mediators such as interleukin (IL)-1B, IL-6, IL-8 and TNF-, which are upregulated in many ocular diseases, increase the expression of ROS, which likewise lead to enhanced secretion of inflammatory cytokines, chemokines, and matrix-remodeling factors, thus altering local environment homeostasis, and finally contributing to the maintenance of a vicious circle of chronic inflammation and oxidative stress. Of all the vision-supporting nutrients you can add to your supplementation routine, lutein and zeaxanthin are at the top of the list. Cicero A.F., Allkanjari O., Busetto G.M., Cai T., Largan G., Magri V., Perletti G., Robustelli Della Cuna F.S., Russo G.I., Stamatiou K., et al. Clinical Trials Studying Astaxanthin Astaxanthin for Eye Health How Does Astaxanthin Work? Similar results were reported by Suzuki and coauthors, who adopted the same designed model of the study cited above, confirming the anti-inflammatory effectiveness of the microalgae-derived carotenoid, as suggested by reduced cellular infiltration, protein concentration and cytokines levels in the aqueous humor of a uveitis mice model [54]. Further, due to the presence of two stereogenic carbon atoms at the 3,3 positions, three different stereoisomers of astaxanthin, including a pair of enantiomers (3R,3R- and 3S,3S-astaxanthin) and an optically inactive mesoform (3R,3S-astaxanthin) may be found, as shown in Figure 1 [1]. Following uveitis induced by a footpad injection of lipopolysaccharide (LPS), astaxanthin or prednisolone were administered intravenously 30 minutes before, at the same time as, or 30 minutes after LPS treatment. On this basis, nutraceuticals like astaxanthin may be used not only to fill the nutritional gap (supplement use), but also to treat various pathological conditions by synergistically acting with conventional therapies (therapeutic use). ), 2Ophthalmology Unit, S.Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy; ti.liamtoh@inirgellep.ocram (M.P. Not by chance, it has shown multiple beneficial effects including anticancer, antidiabetic, anti-inflammatory and antioxidant activities, as well as protective actions for skin and nervous and cardiovascular systems [1,4,5]. It has been reported that astaxanthin can suppress H2O2-induced NF-B activation by inhibiting intracellular ROS accumulation. Astaxanthin Supplements. Regardless of the time of astaxanthin administration, all treated groups achieved neuroprotective effects due to astaxanthin effectiveness in downregulating both oxidative and inflammatory cascades. In another multicenter, prospective, open-label randomized study, AMD patients treated with a combination of lutein/zeaxanthin and astaxanthin over a two-year period were more likely to report a significant improvement in visual acuity, contrast sensitivity and vision-related functions [41]. As a consequence, increased levels of cytokines have been documented in tears and aqueous humor of patients suffering either with corneal or retinal diseases [17,18]. Additionally, a recent study showed that astaxanthin supplementation delayed the development and progression of metabolic cataracts by inhibiting oxidative stress in diabetic mouse models, as demonstrated by a significant reduction in the levels of advanced glycation end products [58]. Yamagishi R., Aihara M. Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis. *. Furthermore, the use of astaxanthin in the medical field is of recent interest, with the purpose of improving health status. Samples were fed with astaxanthin (4.8 mg/kg of body weight) once a day for one week. Unlike most antioxidants which work in the inner (e.g., vitamin E and -carotene) or in the outer side of the membrane (e.g., vitamin C), astaxanthin stretches through the bilayer membrane, providing protection against oxidative stress by scavenging reactive oxygen species (ROS) in both the inner and outer layers of the cellular membrane [4,5]. 10 milligrams lutein. The .gov means its official. Suzuki Y., Ohgami K., Shiratori K., Jin X.H., Ilieva I., Koyama Y., Yazawa K., Yoshida K., Kase S., Ohno S. Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway. Results showed a marked reduction of AR activity in vivo and ex vivo following astaxanthin supplementation, thus supporting its role in both the prevention and early treatment of diabetic retinopathy [44]. Scorcia V., Soda M., Lucisano A., Lanza M., Giannaccare G. A Preliminary Comparative Study of Visual Performance Between Two Newly Commercially Available Monofocal Intraocular Lenses Implanted During Cataract Surgery. One study looked at the effects of an antioxidant supplement (anthocyanosides, astaxanthin, vitamins A, C, E, and herbal extracts) and a placebo in patients with dry eye disease for eight weeks. Astaxanthin has become a popular choice for those looking to support their eye health. Song X.D., Zhang J.J., Wang M.R., Liu W.B., Gu X.B., Lv C.J. * "They've done studies with astaxanthin to show it does help people who are looking at computer screens all day," he shares, noting astaxanthin's ability to support reset and recovery.*. Antioxidant powerhouse astaxanthin helps our eyes focus and refocus while working on our screensand aids reset and recovery when we step away from them.