J Ethnopharmacol. Protective effects of Withania somnifera extract in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Life Extension, Arjuna Natural Ltd., Sabinsa Corp, Naturalin Bio-Resources Co Ltd., Kerry Group, Ixoreal Biomed Pvt Ltd., Umalaxmi Organics Pvt Ltd., OmniActive Health Technologies Limited. ChronoscreenTM Analysis: Cognition Enhancing Drugs & Natural Extracts. We do not verify or endorse any claims made in these reviews. Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts. Atluri VSR, Tiwari S, Rodriguez M, et al. Mathur R, Gupta SK, Singh N, et al. It helps relieve stress and improves symptoms of anxiety and depression. Your cortisol levels are higher in the morning, helping you to jumpstart your body for the day ahead, and will later drop at night when it is time to unwind. ", Gorelick, Jonathan. 17. If youre looking to consume ashwagandha for general health promotion, its recommended to take it on an empty stomach in the morning, says Snyder. Preclinical studies have shown that ashwagandha: Animal models of Alzheimer's also show a drop in two key proteins associated with brain maintenance and repair: brain-derived neurotrophic factor (BDNF) and glial fibrillary acidic protein (GFAP). Normal levels of glutamate are vital to brain communication.4, But very high levels of glutamate can cause excitotoxicityoverstimulation of brain cells that can cause them to go haywire, and even die. Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Supports a healthy response to everyday stress, Encourages already-healthy levels of the stress hormone cortisol. Please subscribe to get email updates on this blog. Find out which mood-boosting nutrients can keep the stress away. Life Extension Optimized Ashwagandha Roman Testosterone Support Supplements Terra Origin Inner Balance For Stress & Tension Apothekay Ashwagandha Ashwagandha is an herb that has been used for centuries in Indian Ayurvedic medicine. 7,318,938 and is a registered trademark of Natreon, Inc. To report a serious adverse event or obtain product information, contact 1-866-280-2852. Hum Exp Toxicol. It contains both the root and leaf, and 10 percent withanolide, so its very potent, she adds. When ashwagandha extract was administered by re-searchers one hour before a daily stress-inducing procedure, all of the aforementioned parameters of free radical damage normalized in a dose-dependent manner.2 Premature aging associated with chronic nervous tension may be related to increased oxidative stress, which is abolished by the potent antioxidant properties of ashwagandha extract. We asked nutrition experts from all over the world to weigh in on the best ashwagandha supplements, evaluating each formula on active ingredients, type, dosage, and benefits targeted. Some people also use ashwagandha for improving thinking ability, reducing pain and swelling, and to increase libido, says Bah. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. 25 results for "life extension ashwagandha" Results Price and other details may vary based on product size and colour. I tried Ashwagandha for the first time 2-3 months ago but from a different brand . I love this supplement, whichcomes in powder form and can be easily added to smoothies, lattes, or other warm drinks, says Gena Hamshaw, RD, a registered dietitian in New York City and author ofThe Full Helpingblog. Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke. All of these situations can make it harder to support our already-healthy cortisol levels, and ultimately influence how our nervous system functions. 14. Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer treatment. Clinical evidence demonstrated that this proprietary extract increased memory performance in older adults by nearly 60% and improved attention by 250%within hours of ingestion.39, In addition to enhancing cognitive function in humans, this unique sage extract has been shown to increase lifespan by 12% in a C. elegans model of aging.40. More information at www.consumerlab.com/survey. 2005 Mar;12(3):229-35. Its on NOW! When it comes to choosing an ashwagandha supplement,Kimberly Snyder, a plant-based nutritionist and holistic wellness expert, says that first and foremost, you want to make sure it has theUSDA organic stamp. The most powerful components of the ashwagandha plant come from the root, but the leaves and fruits are often used as well. Shop Now 20% off Brain & Cognitive! Kumar P, Singh R, Nazmi A, et al. Similarly, in a rodent model of skin cancer, ashwagandha inhibited tumor incidence and multiplicity by 45% and 71%, respectively.16 Ashwagandhas protective effect against skin cancer has been shown in other studies as well.17. Price at time of publish: $20 for 60 count, Type: Capsule | Key Ingredients:Organic ashwagandha powder, organic ashwagandha extract, organic ashwagandha supercritical C02 extract |Age Range:Adult 18+ |Dosage:1 capsule |Certified:USDA organic, non-GMO, GMP, Good Laboratory Practice Certification, Manufacturing facility also processes fish extracts, Many ashwagandha supplements sell online, but heres one you may be able to find in your local drugstore. Having a low testosterone level can speed up the signs of aging and impact sexual stamina and performance. These actions, along with its other benefits, make ashwagandha a powerful neuroprotective nutrient. Unpublished study, 2005. Adaptogens increase resistance to the adverse effects of stress (mental, emotional, and physical). Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. Glioprotective effects of Ashwagandha leaf extract against lead induced toxicity. Life Extension does not provide medical advice, diagnosis, or treatment. In another study, orally administered ashwagandha extract significantly inhibited experimentally induced stomach cancer in laboratory animals. Some brain injuries, such as traumatic head injuries and stroke, cause a huge release of glutamate that results in further cell death.4, Glutamate excitotoxicity has been found to be a component of the pathology seen in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, ALS, and multiple sclerosis.4, Ashwagandha defends the brain against this damage. Research shows ashwagandha works to reduce stress, in part, because the herb reduces activity in one's HPA axis the part of the brain in charge of regulating stress response. There are multiple forms of ashwagandha root available for consumption. Studies indicate that testosterone drops in men by about 1% each year, beginning around the age of 30. | FREE SHIPPING on orders $50+. The results were impressive. Glutamate is an amino acid that acts as a neurotransmitter in the brain. Additionally, laboratory analysis indicates that ashwagandha extract possesses anti-angiogenic activity, also known as the ability to prevent cancer from forming new blood vessels to support its unbridled growth. The fruits of the ashwagandha plant should be mature but not dried out, which is when the active principles are the highest.. 15. What is cortisol? Mathur S, Kaur P, Sharma M, et al. 2005 Apr;144(7):961-71. Vinutha B, Prashanth D, Salma K, et al. As a supplement, it has been shown to support the bodys stress response, which is a very common cause of restless nights, she says. Anna Harris is an experienced fact-checker and researcher and a beauty writer and editor. Shop discontinued formulas and save. (2) Life Extension Rest & Renew formula includes the clinically studied dose of Shoden ashwagandha (120 mg). 100+ bought in past week. Many clinical trials show ashwagandha offers a wide range of benefits, and helps balance the bodys response to stresses of day-to-day living. If you are looking for a supplement that supports your mind and bodyfrom mood support to maintaining already-healthy blood sugar levelsturn to ashwagandha for full-spectrum coverage. They also act in other ways to protect the brain from disease. Ashwagandha has powerful antioxidant properties that seek and destroy the free radicals that have been implicated in aging and numerous disease states. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Maity T, Adhikari A, Bhattacharya K, et al. And that's not all! Last Updated: 08/29/2022 Initially Posted: 06/16/2018 Summary Does ashwagandha work? 2000 Jun 26;11(9):1981-5. Best Seller Zinc Caps Support the body's immune defenses, ultra-absorbable 50 mg, 90 vegetarian capsules 4.9 (647) $6.75 Add To Cart Vitamin D3 2011;6(11):e27265. While all parts of the plant are used, the roots are often used for their botanical properties. Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. Roots of Withania somnifera inhibit forestomach and skin carcinogenesis in mice. Ashwagandha may protect against various forms of dementia. 2011;8(5S). Ashwagandha supplements can help with everything from stress to sleep to brain health. Mukherjee S, Kumar G, Patnaik R. Withanolide a penetrates brain via intra-nasal administration and exerts neuroprotection in cerebral ischemia reperfusion injury in mice. 2000 Jul;71(1-2):193-200. Enable collaborative features and customize widget: An error on our end has caused the item you were trying to add to your cart to fail, please try again or call, Ashwagandha has been hailed for its potential benefits, promote already-healthy levels of cortisol, testosterone levels in men drop 1.6% each year, https://pubmed.ncbi.nlm.nih.gov/19501822/, https://pubmed.ncbi.nlm.nih.gov/23439798/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544367/, https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha, Ahmad, Mohammad Kaleem et al. If you know of one we should consider, please email us atcontact@byrdie.comand we will evaluate the product ASAP. Feeling out of sorts? It's the hormone your adrenal gland secretes when your body has a "fight or flight" response to immediate or perceived threats of danger. These statements have not been evaluated by the Food and Drug Administration. Supporting cognition, memory, healthy stress response, and overall well-being. Altern Med Rev. to 32% oligosaccharides, 10% withanolide glycoside conjugates]. More information at www.consumerlab.com/survey. Khalid S, Barfoot KL, May G, et al. 10. All rights reserved. The participants taking ashwagandha also had improvements in physical parameters related to stress such as stress-related muscle tension.2 Again, at the higher doses, greater improvements were seen. For the best experience navigating LifeExtension.com, we recommend switching to any of the following browsers: Life Extension does not provide medical advice, diagnosis, or treatment. Here's where ashwagandha comes inthis herb has been shown to promote healthy levels of cortisolwhich may specifically help when faced with "fight or flight" situations. Its on NOW! Enable collaborative features and customize widget: An error on our end has caused the item you were trying to add to your cart to fail, please try again or call, the powerful properties of ashwagandha as an adaptogen, https://pubmed.ncbi.nlm.nih.gov/19789214/, https://pubmed.ncbi.nlm.nih.gov/23439798/, https://pubmed.ncbi.nlm.nih.gov/28471731/, https://pubmed.ncbi.nlm.nih.gov/25796090/, https://www.insider.com/ashwagandha-benefits, Abbas, Ali Mahdi, et al. Shop Now Popular Products Explore some of our most popular vitamin and supplement products. Optimized Ashwagandha Extract, 60 vegetarian capsules - Life Extension Vitamins & Supplements Stress Management Optimized Ashwagandha Extract Click to Zoom Best Seller Optimized Ashwagandha 60 vegetarian capsules Item # 00888 Promotes a healthy response to stress 4.8 261 Reviews | Write a review Don't let stress weigh you down. Shop Now Last Chance Skin Care It's a beauty of a sale! Attari M, Jamaloo F, Shadvar S, et al. It would appear from this study that ashwagandha can address many of the health and psychological issues that plague todays society.4. Its botanical properties are believed to provide the strength and energy of a horse. It's smart to supplement with ashwagandha if you're seeking optimal cognitive health! This remarkable herb also grows new nerve cells and inhibits the growth of human breast, lung, colon, and other cancer cells. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. The most notable benefit ashwagandha supplements offer is their effect on lowering stress levels, says Bah. All rights reserved. Some medications used to treat Alzheimer's inhibit the enzyme that breaks down acetylcholine, boosting its levels. A study on evalution of antidepressant effect of imipramine adjunct with Aswagandha and Bramhi. Talk about brilliant! 278. By Life Extension 5809 Reviews | 31 & 187 Roll over image to zoom in In Stock Best By: January 2025 Date First Available: April 2009 Shipping Weight: 0.1 lb Product Code: LEX-88806 UPC Code: 737870888062 Package Quantity: 60 Count Dimensions: 3.5 x 1.9 x 1.9 in, 0.1 lb Product rank: #2 in Ashwagandha Ashwagandha is a whole-body health superstar, potentially supporting everything from already-healthy blood sugar levels, to hormone balance, to a positive mood. For example, a recent analysis showed that ashwagandha extract inhibited the growth of human breast, lung, and colon cancer cell lines in the laboratory. Full product reviews disclaimer. Neurodegenerative diseases and Withania somnifera (L.): An update. Some of its potential benefits include supporting: Ashwagandha also offers benefits for when your head hits the pillow, providing you with calming effects to promote better sleep quality. 2004 Jul;11(5):452-60. PlantVital Ashwagandha Capsules with Black Pepper 1300mg, 120 Ashwagandha Capsules - Ashwagandha for Energy Increase and Memory Enhancement - Anti Stress and Sleep Aid Ashwagandha Supplement Adult 1,203 $2995 ($0.25/count) Take one (1) capsule twice daily on an empty stomach, or as recommended by a healthcare practitioner. Antioxidant Effects The natural antioxidants in ashwagandha may improve overall health and promote better fat burning. At $40 for 30 grams, the powder is a bit of a splurge, but we vote that it's worth it. Our Optimized Ashwagandha delivers a standardized extract of Withania somnifera, an Ayurvedic herb known to help relieve the effects of everyday stress. Sensoril is protected under US Patent No. Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial. Bhattacharya SK, Bhattacharya A, Sairam K, et al. Scholey AB, Tildesley NT, Ballard CG, et al. Is stress keeping you up at night? Because it is calming, it is also thought to support sleep. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males., Chandrasekhar, K et al. 2001 Apr;45(2):253-7. Life Extension Magazine Ashwagandha: Stress Reduction, Neural Protection, and a Lot More from an Ancient Herb In scientific studies, the Indian herb ashwagandha has demonstrated stress-relieving effects comparable to those of prescription drugs. Price at time of publish: $9 for 60 count, Type: Capsule | Key Ingredients:Sensoril ashwagandha extract |Age Range:Adult |Dosage:1 capsule |Certified:cGMP-certified by NSF International. 11. The 9 Best Vegan Protein Powders of 2023, According to Dietitians, The 9 Best Apple Cider Vinegar Supplements of 2023, The 17 Best Multivitamins for Women of 2023, The 11 Best Hair, Skin, and Nail Vitamins of 2023, 11 Beauty and Health Supplements Actually Worth Taking, The 15 Best Protein Powders for Women of 2023, The 11 Best Vitamins for Clear Skin in 2023, The 9 Best Protein Bars for Women of 2023. Ashwagandha (Withania somnifera) helps your body manage the physiological effects of stress. Of course, not all of this information may be listed on a product label, so be sure to do your research or reach out to a brand directly before making a purchase. Ratings based on results of the 2023 ConsumerLab.com Survey of Supplement Users. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. 12 Best Ashwagandha Supplements (2022) According to Experts The Best Ashwagandha Supplement: Reviews and Buyer's Guide Published by Jason Hughes Fact Checked Fact checked by Mark Johnson Last Updated: September 30, 2019 We live in an anxious world, especially with the coronavirus pandemic rearing its ugly head. Phosphatidylserine is a phospholipid, one of the structural components of the membranes that surround all cells in the body.41,42 This is especially critical for nerve cells in the brain, because it is their cell membranes that carry nerve impulses throughout the nervous system.43 The myelin that surrounds nerve fibers and aids signal Organic Ashwagandha supercritical CO2 extract (root) (Withania somnifera Dunal) (8% Withanolides, 0.8 mg), Organic Ashwagandha extract (root) (0.5 % Withanolides, 1.4mg), Organic Ashwagandha powder (root) (0.2% Withanolides, 0.76 mg), Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. Ashwagandha may help promote already-healthy levels of cortisol, even when youre reacting to stressful situations. Ashwagandha is a powerful male health herb because it may help keep testosterone production within a normal, healthy range, supporting healthy hormone balance. Plus, ashwagandha has been linked to better exercise performance and endurance. Both well-being and general fatigue scores significantly improved in all groups given ashwagandha by day 30 and further improved by day 60and again, no improvements were seen in the placebo group.2, Sensoril Ashwagandha extract (root and leaf) [std. Additionally, ashwagandha has been used for inducing sleep, however, this herb should only be used under a doctor's supervision due to possible interactions with certain types of medications. All Contents Copyright 2023 Life Extension. Effect of Withania somnifera Dunal Root Extract on Behavioral Despair Model in Mice: a Possible Role for Nitric Oxide. The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model. Wonderful Ashuwangada! Our best overall pick is the Life Extension Optimized Ashwagandha. The ashwagandha plant is a short, small shrub with orange berries that resemble tomatoes. Life Extension Ashwagandha Extract Veg Capsules, 60-Count, 60ct: Buy Online at Best Price in UAE - Amazon.ae Health Diet & Nutrition Vitamins, Minerals & Supplements AED7999 FREE delivery Thursday, 1 June on your first order Or fastest delivery Tomorrow, 30 May. Several studies in animals and humans have reported beneficial effects for the brain.49. Kuboyama T, Tohda C, Komatsu K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. Active compounds in ashwagandha support a range of healthy functions. Ashwagandha benefits. Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment. Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment. Published: June 2021 Ashwagandha's health benefits have been hailed for thousands of years, but if you've never heard of this ancient herbal extract, you may be wondering what all the buzz is about. Ashwagandha in brain disorders: A review of recent developments. Our Optimized Ashwagandha Extract contains Sensoril Ashwagandha extract made from both the root and leaf and is standardized to 32% oligosaccharides and 10% withanolide glycoside conjugates. Blueberries are packed full of anthocyanins, powerful compounds that help protect the plant from oxidative stress. Here is everything you need to know about ashwagandhaand why this powerful adaptogenic herb deserves a spot in your wellness routine. 2001 Jan;74(1):1-6. Baitharu I, Jain V, Deep SN, et al. 4.5 out of 5 stars 664. Life Extension, Optimized Ashwagandha, 60 Vegetarian Capsules By Life Extension 5477 Reviews | 31 & 187 Roll over image to zoom in In Stock Best By: February 1 2025 Date First Available: April 15 2009 Shipping Weight: 0.1 lb Product Code: LEX-88806 UPC Code: 737870888062 Package Quantity: 60 Count Dimensions: 3.5 x 1.9 x 1.9 in, 0.1 lb Best seller Aging is associated with structural deterioration in the nervous system, which may be reduced by phosphatidylserine's ability to preserve cognitive function. This important research may one day benefit those who have incurred brain injuries due to physical trauma, as well as those who suffer cognitive decline due to destruction of the nerve cell networks from diseases such as dementia and Alzheimers. Himalaya Ashwagandha Capsules are less than 50 cents per capsule. What does it mean to support healthy brain cells? Ashwaganda is an "adaptogen". That's why you'll also find that some ashwagandha supplements are formulated specifically to help with sleep, like this one. From Japan! 5. 1998 Apr;42(2):299-302. . If youre pregnant, please speak with your doctor before starting any new supplements. Read our, Life Extension Optimized Ashwagandha at Amazon, Integrative Therapeutics Cortisol Manager at Amazon, Nootropics Depot Ashwagandha Extract Powder at Amazon, Moon Juice Stress Management Supplement at Amazon, What to Look For in an Ashwagandha Supplement, Integrative Therapeutics Cortisol Manager, Nootropics Depot Shoden Ashwagandha Extract Powder, Moon Juice SuperYou Daily Stress Management Supplement, Maharishi Ayurveda Worry Free Calm Remedy. 10 Best Herbs for Energy: How to Fight General Fatigue. These drugs have side effects, including fatigue and cognitive impairment. Find out which mood-boosting nutrients can keep the stress away. She loves taking care of the family as a wholefrom the cradle to the grave. The ashwagandha plant is a short, small shrub with orange berries that resemble tomatoes. Discover nutrients you need for optimal health, Stay informed with Life Extension Magazine, From basic health panels to genetic testing, 1-800-226-2370 -ThisserviceisFREE8-1 AM Mon-Fri | 9-1 AM Sat-Sun (ET). Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats. Padmavathi B, Rath PC, Rao AR, Singh RP. Ashwagandha stimulates these same GABA receptors, without the side effects.14,15 Rather than causing fatigue or cognitive impairment, ashwagandha is known to enhance cognitive performance.5, Ashwagandha has long been used to reduce stress and support a healthy mood.14 A review of human trials found that it improved anxiety symptoms, compared to a placebo.6, In animal models of depression, ashwagandha extracts reverse signs of behavioral despair and other abnormalities and improve cognitive function.16-19, In two studies in rodents, the magnitude of this impact was comparable to the effects of imipramine and fluoxetine (Prozac), two drugs used in humans to treat depression and other disorders.16,17, In patients with schizophrenia, who are prone to anxiety and depression, an ashwagandha extract reduced symptoms of both.20. This is my top pick, as it contains 125 milligrams of ashwagandha and 300 milligrams of magnesium, says Allison Koch, PhD, RDN, a dietitian and RRCA-certified coach in Hickory, NC. Drugs currently used in the treatment of Alzheimers disease, such as Aricept, act in this very manner to slow the progression of this frightening, mind-robbing disease.9, In addition to ashwagandhas documented neuroprotective effects, exciting recent evidence suggests that it also has the potential to stop cancer cells in their tracks. 11. Immunopharmacol Immunotoxicol. Stress can cause increased peroxidation of lipids, while decreasing levels of the antioxidant enzymes catalase and glutathione peroxidase. Ratings based on results of the 2023 ConsumerLab.com Survey of Supplement Users. By 5:15 I was feeling some heaviness in my chest and my legs were more wobbly than with my everyday anxiety. I can honestly say this was my go-to supplement that I was excited to find extremely helpful during the very stressful work-from-home days of 2020., Price at time of publish: $13 for 54 count, Type: Capsule | Key Ingredients:Magnesium oxide and Sensoril ashwagandha |Age Range:Adult 18+ |Dosage:2 capsules |Certified:USP verified. Internet Explorer is no longer supported by many websites. Nutrition. | FREE SHIPPING on orders $50+. Fibrinolytic effects of Ginkgo biloba extract. Ashwagandha has been hailed for its potential benefits for memory, vitality, hormone function, weight management and the nervous system. Research shows that ashwagandha may help protect against forms of dementia, including. Feeling out of sorts? You can ingest ashwagandha root extract, ashwagandha powder, or an ashwagandha capsule. Ashwagandha enhanced the reported well-being and energy level scores of study participants as well. This herb is gaining. The participants showed several measurable improvements, including a reduction of cortisol levels up to 26%, a decline in fasting blood sugar levels, and improved lipid profiles. These products are recommended based on your quiz answers. 2023 Consumer Satisfaction, Rated #1 Catalog/Internet Merchant. This buildup inflicts toxic effects on brain cells and incites aggressive chronic inflammation, which leads to further deterioration of brain function. An avid traveler, Andrew also has volunteered as an English teacher and humanitarian in countries throughout Asia. Feeling frazzled? Ashwagadandha can naturally lower cortisol levels up to 26 percent, reports the Life Extension Magazine article "Stress Reduction, Neural Protection, and a Lot More from an Ancient Herb" by Dale Kiefer. Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera. 2. Tantalizing evidence suggests that ashwagandha may also be a cancer fighter. Antioxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum.
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