1 kg x 12 bags HONDASHI is the world's best seafood stock. In animal models, pharmacological inhibition of ischemic succinate accumulation ameliorated ischemia-reperfusion injury. Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. 45, # 11 p. 2873 - 2882. Substances predicted as likely to meet criteria for category 1A or 1B carcinogenicity, mutagenicity, or reproductive toxicity, or with dispersive or diffuse use(s) where predicted likely to meet any classification criterion for health or environmental hazards, or where there is a nanoform soluble in biological and environmental media. Substances which have been registered and can be placed on the EEA market by those companies with a valid registration. Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. (628), Dipotassium Inosine-5'-Monophosphate* The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). Canned seafood (fish, shellfish, cuttlefish), What is Hydrolyzed Soy Protein or HVP: Uses, Safety and Side Effects, What Is Disodium 5-ribonucleotides (E635) In Food? the electronic edition of the Official Journal of the European Union. Uses advised against Food, drug, pesticide or biocidal product use. [33] Therapies targeting succinate to reduce cardiovascular risk and hypertension are currently under investigation.[28]. [30][32], Extracellular succinate regulates cardiomyocyte viability through GPR91 activation; long-term succinate exposure leads to pathological cardiomyocyte hypertrophy. manufacturing of the substance. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. di-Sodium succinate Write a review anhydrous for synthesis Synonym (s): di-Sodium succinate, Succinic acid disodium salt Empirical Formula (Hill Notation): C4H4Na2O4 CAS Number: 150-90-3 Molecular Weight: 162.05 MDL number: MFCD00002790 EC Index Number: 205-778-7 Pricing and availability is not currently available. Master Food Chinese Stir Fry Sauce containing Disodium appears to have caused me to come up in a rash. (470(i)), Salts of oleic acid with calcium, potassium and sodium Disodium Succinate is a disodium salt of Succinic Acid (q.v.). [18], Acylation with succinic acid is called succination. (504(ii)), Methacrylate copolymer, basic (BMC) ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. Succinic acid is marketed as food additive E363. (472b), Lactic and fatty acid esters of glycerol (1209), Propane-1,2-diol esters of fatty acids* [17] Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. Succinate requires specific transporters to move through both the mitochondrial and plasma membrane. Disodium succinate is thedisodiumsalt ofSuccinic acid. Butanedioic acid, s odium salt (1:2) [ACD . . by professional workers (widespread uses), Halal Certificate. REACH regulationaims to improve the protection of human health and the environment from the risks that can be posed by chemicals. CAS Common Chemistry is provided under the Creative Commons Attribution-NonCommercial 4.0 International License, or CC BY-NC 4.0 license. (953), Lactic and fatty acid esters of glycerol GABA is then metabolized by GABA transaminase to succinic semialdehyde. Pricing. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance): Welcome to the ECHA website. Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Disodium succinate, 98%. More information about CAS and the CAS registry can be found here. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. La Roche-Posay La Roche-Posay Toleriane Double Repair Face Moisturizer, SPF 30, 2.5 oz. The quantity of sodium carbonate or sodium hydroxide should be excessive, otherwise, monosodium succinate would be obtained. ). Uses, Safety, Side Effects, All about Gelatin: Sources, Types, Made of, Production, Uses and More. The glyoxylate cycle is utilized by many bacteria, plants and fungi and allows these organisms to subsist on acetate or acetyl CoA yielding compounds. (965(i)), Irish moss gelose (from Chondrus spp. (1100(iv)), alpha-Amylase from Bacillus stearothermophilus Both can be used as flavor enhancers in Japan, but seldom used in Europe. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. Under pathological and physiological conditions, the malate-aspartate shuttle or the purine nucleotide shuttle can increase mitochondrial fumarate, which is then readily converted to succinate. 2012 Feb;13(2):103-10. Product Name Sodium Succinate Hexahydrate Cat No. Thus, succinate is thought to play a role in liver homeostasis. [30] Stimulation of GPR91 triggers at least two signaling pathways in the heart: a MEK1/2 and ERK1/2 pathway that activates hypertrophic gene expression and a phospholipase C pathway which changes the pattern of Ca2+ uptake and distribution and triggers CaM-dependent hypertrophic gene activation. [35] Succinate may interfere with the enzymatic process by attaching to the Fe(II) center first, prohibiting the binding of 2-oxoglutarate. Stable. Enzymes required for the GABA shunt are expressed in neurons, glial cells, macrophages and pancreatic cells. Jalloh et al. About Us | [22]:Section 17.4, Succinate is the re-entry point for the gamma-aminobutyric acid (GABA) shunt into the TCA cycle, a closed cycle which synthesizes and recycles GABA. Do not show this message again. It contains a succinate (2-). you're details won't be shared. Uses, Benefits, Safety, Side Effects, What Is Erythritol (E968) In Food? in formulation or re-packing, Oversuccination occurs when more than one succinate adds to a substrate. [8] ROS then trigger the cellular apoptotic machinery or induce oxidative damage to proteins, membranes, organelles etc. Applications Products Services Support. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. ECHA has no public registered data indicating whether or into which articles the substance might have been processed. Mutations in SDH, hypoxia or energetic misbalance are all linked to an alteration of flux through the TCA cycle and succinate accumulation. Please note: The Codex General Standard for Food Additives is currently under development and it will be regularly updated to include additional food additive provisions adopted by the Codex Alimentarius Commission. To go to main food additive page, click here. More information about Classification and Labelling is available in the Regulations section of ECHA website. (150d), Carbohydrase from Bacillus licheniformis (1100(vi)), -Carotene-rich extract from Dunaliella Salina (161b(iii)), Magnesium Subcarbonate (Light or Heavy)* (476), Polyvinyl alcohol (PVA) Polyethylene glycol (PEG) graft copolymer [40] In spite of a general downregulation of the TCA cycle under these conditions, succinate concentration is increased. This is unique source of information on the chemicals manufactured and imported in Europe. (468), Diacetyltartaric and fatty acid esters of glycerol Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EUs mechanism for protecting the health of workers. Disodium succinate crystalline has two types, anhydrous (CAS number 150-90-3) and hexahydrate (CAS number 6106-21-4, contains six crystal water), the latter is the most used than the former in food. Flavors & Fragrances; W327700; . [10] 1,4-Butanediol (BDO) can be synthesized using succinic acid as a precursor. The molecular structure is based on structures generated from information available in ECHAs databases. laboratory chemicals and According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified. Since ECHA aims to devote our maximum effort to this new system, we can no longer maintain REACH registration data on the current Dissemination Platform. Recommended Use Laboratory chemicals. By using CAS Common Chemistry, you agree to the terms and conditions of this license. The factsheets will remain online, but will not be updated. Common industrial routes include hydrogenation of maleic acid, oxidation of 1,4-butanediol, and carbonylation of ethylene glycol. Go to the Color Additives Status List. . This is the first study to analyse the effect of muscle glycogen phosphorylase depletion in metabolically different muscle types. Basic Attributes Molecular Weight 162.05200 Exact Mass 161.99000 EC Number 205-778-7 UNII V8ZGC8ISR3 DSSTox ID DTXSID5059741 1 0 obj << /Type /Page /Parent 164 0 R /Resources 2 0 R /Contents 3 0 R /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 >> endobj 2 0 obj << /ProcSet [ /PDF /Text ] /Font << /TT2 176 0 R /TT4 181 0 R /TT5 148 0 R >> /ExtGState << /GS1 182 0 R >> /ColorSpace << /Cs6 177 0 R >> >> endobj 3 0 obj << /Length 1765 /Filter /FlateDecode >> stream (470(ii)), Sodium carboxymethyl cellulose, enzymatically hydrolysed (Cellulose gum, enzymatically hydrolyzed) [6][22]:Section 17.1 All metabolic pathways that are interlinked with the TCA cycle, including the metabolism of carbohydrates, amino acids, fatty acids, cholesterol, and heme, rely on the temporary formation of succinate. CIR (Cosmetic Ingredient Review). (423), Polyglycerol esters of interesterified ricinoleic acid In that case, the ATP (Adaptation to Technical Progress) number is displayed. You'll be the first to know when we come to your area! [12] Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate. [31] SDH mutations have also been identified in gastrointestinal stromal tumors, renal tumors, thyroid tumors, testicular seminomas and neuroblastomas. struggle with their purchases at grocery stores around the world. CAS Number: 150-90-3. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. Succinic acid (/sksnk/) is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2. [7][32] Succinate may enhance adaptive immunity by triggering the activity of antigen-presenting cells that, in turn, activate T-cells. Thus, via enzymatic inhibition, increased succinate load can lead to changes in transcription factor activity and genome-wide alterations in histone and DNA methylation. Synonyms Disodium succinate hexahydrate Recommended Use Laboratory chemicals. [6] The intermediate is made available for biosynthetic processes through multiple pathways, including the reductive branch of the TCA cycle or the glyoxylate cycle, which are able to drive net production of succinate. This page contains an index of individual food additives or food additive groups (indicated in UPPERCASE). Grocery shopping shouldnt be hard or unenjoyable, and yet every day millions of shoppers [32] In inflammatory macrophages, succinate-induced stability of HIF1 results in increased transcription of HIF1-dependent genes, including the pro-inflammatory cytokine interleukin-1. Other useful links: Click here to view the current version of the Codex, JECFA reports and toxicological monographs, North America and South West Pacific (CCNASWP). Its thermal stability also enables it to go through a high temperature process in food. Enter the ingredients in EWGs Build Your Own Report tool to get an approximate score for that product. Certificates. 205-778-7, CAS no. This information has not been reviewed or verified by ECHA, and may change without prior notice. The "Codex General Standard for Food Additives" (GSFA, Codex STAN 192-1995) sets forth the conditions under which permitted food additives may be used in all foods, whether or not they have previously been standardized by Codex. Other relevant information includes the following: To see the full list of notified classifications and to get more information on impurities and additives relevant to classification please consult the C&L Inventory. Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Data platform availability banner - infocard, search, nanomaterias, EC Inventory, C&L Inventory, Registration dossier, Pre-Registration process, Other, Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). (1101(i)), Salts of myristic, palmitic and stearic acids with ammonia, calcium, potassium and sodium (460(i)), Mono- and di-glycerides of fatty acids Molecular Weight: 162.05. Color additives, 21 CFR Parts 70, 71, 73, 74, 80 & 82. Upload a receipt and begin the discovery process, Note: You can upload multiple images. [5] In an aqueous solution, succinic acid readily ionizes to form its conjugate base, succinate (/sksnet/). More Documents. Canadian Environmental Protection Act (CEPA) Environmental Registry. Uses advised against Food, drug, pesticide or biocidal product use. [27] The GABA shunt serves as an alternate route to convert alpha-ketoglutarate into succinate, bypassing the TCA cycle intermediate succinyl-CoA and instead producing the intermediate GABA. Substances for which classification and labeling data have been submitted to ECHA in a registration under REACH or notified by manufacturers or importers under CLP. (316), Sucralose (Trichlorogalactosucrose) This substance is used for the manufacture of: Disodium succinate 98% Synonym (s): Succinic acid disodium salt, Sodium succinate dibasic Linear Formula: NaOOCCH2CH2COONa CAS Number: 150-90-3 Molecular Weight: 162.05 FEMA Number: 3277 Beilstein: 3917246 EC Number: 205-778-7 MDL number: MFCD00002790 PubChem Substance ID: 24901603 (Flavis) : 8.113 NACRES: NA.21 Recommended Products scientific research and development. The described Product category (i.e. [37][41] Loss-of-function mutations in the genes encoding succinate dehydrogenase, frequently found in hereditary paraganglioma and pheochromocytoma, cause pathological increase in succinate. If generated, an InChI string will also be generated and made available for searching. The number of dead cells was determined based on the number of PI-positive/Hoechst positive cells and the . The hexahydrate form is used as an ingredient of topical preparations for the treatment of cataract. [24][27] In rodents, mitochondrial concentrations are approximately ~0.5 mM[6] while plasma concentration are only 220 M. (1100(ii)), alpha-Amylase from Bacillus stearothermophilus expressed in Bacillus subtilis Disodium succinate is a white powder with a melting point of more than 400 degree C, a water solubility of more than 100 g/L. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. High concentrations of succinate will mimic the hypoxia state by suppressing PHDs,[37] therefore stabilizing HIF1 and inducing the transcription of HIF1-dependent genes even under normal oxygen conditions. Clicking on "Show synonyms" will display food additive synonyms. To begin with this system will take over the responsibility of making REACH registration data available, once it is ready. . (472a), Acetic and fatty acid esters of glycerol This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at 100 to < 1 000 tonnes per annum. (472c), Cross-linked sodium carboxymethyl cellulose (Cross-linked-cellulose gum) CAS 150-90-3, chemical formula NaOOCCHCHCOONa. As such once the IUCLID format change begins on 19th May 2023 we will no longer update REACH registered substance factsheets. chemicals. [O-]C (=O)CCC ( [O-])=O. (951), Bengal, Ceylon, Chinese or Japanese isinglass* ECHA has no data from registration dossiers on the precautionary measures for using this substance. Get listed here - [emailprotected]. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically generated for the InfoCard. Disodium succinate is commonly found in shellfish, shrimp, crab and other crustaceans seafood. (1100(vi)), -Carotene-rich extract from Dunaliella Salina Role of Ca ions in oxidative processes. How to enter Lot Number (COO) Search. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. 472f* (472e) Mixed carotenes* (160a(ii)) Mixed Glycerol Esters of Diacetyltartaric Acid and Fatty Acids from Food Fats* (472e) Modified cellulose* (463) Modified Polydextroses* (1200) Monoammonium L-glutamate (624) Mono- and di-glycerides of fatty acids (471) (470(i)), Salts of oleic acid with calcium, potassium and sodium Founder of FoodAdditives.net: major in pharmaceutical in university and have been selling food additives since 2012. The summary and conclusions of recent JECFA meetings and other relevant information, such as call for data for future meetings, are available on the FAO website and the WHO website. Release to the environment of this substance can occur from industrial use: In humans, three HIF prolyl 4-hydroxylases regulate the stability of HIFs. )* MSDS/SDS Database Search | Close W327700. (472e), Mono- and di-glycerides of fatty acids : Succinic acid is a weak diprotic acid that has two PKa, PKa1 4.2 and PKa2 5.6, respectively. Made with dried bonito of the highest quality, HONDASHI delivers unparalleled taste and remarkable cost performance. (1100(i)), alpha-Amylase from Bacillus megaterium expressed in Bacillus subtilis Domestic Substances List Categorization. Pure succinic acid is a solid that forms colorless, odorless crystals. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). (627), Furcellaran agar (from Furcellaria fastigiata)* Sodium succinate (anhydrous) is a sodium salt that is the disodium salt of succinic acid. [14] Succinate can be used to derive 1,4-butanediol, maleic anhydride, succinimide, 2-pyrrolidinone and tetrahydrofuran. (1420), Starch Acetate Esterified with Vinyl Acetate* (472e), Thermally oxidized soya bean oil interacted with mono- and diglycerides of fatty acids CAS 150-90-3. In the retina, succinate accumulates in retinal ganglion cells in response to ischemic conditions. the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure. Note that for readability purposes, only the pictograms, signal words and hazard statements referred in more than 5% of the notifications under CLP are displayed. [6][26][38] PHDs hydroxylate proline in parallel to oxidatively decarboxylating 2-oxyglutarate to succinate and CO2. Lot Number. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism[1]. Whatre the Uses of Potassium Carbonate E501(i) in Food and other Common Applications? Its thermal stability also enables it to go through a high temperature process in food. More information about the EC Inventory can be found here. Last update: . Succinate is also produced from butane via maleic anhydride. Disclaimer, Copyright 2023 ChemSrc All Rights Reserved. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). Mixed acetic and tartaric acid esters of mono and diglycerides of fatty acids; INS No. (500(iii)), Starch Acetate Esterified with Acetic Anhydride* di-Sodium succinate anhydrous for synthesis. This page contains an index of individual food additives or food additive groups (indicated in UPPERCASE). 6H2O CAS Number: 6106-21-4 Molecular Weight: 270.14 Beilstein: 3921044 EC Number: 205-778-7 MDL number: MFCD00149117 PubChem Substance ID: 24899509 NACRES: NA.21 Pricing and availability is not currently available. Dehydration of succinic acid gives succinic anhydride. Phenotype consequences of myophosphorylase dysfunction: insights from the McArdle mouse model. Substances listed in the EINECS, ELINCS, or NLP inventories. they are submitted withing a 5 minute time frame, Acidity regulator - Regulates the acidity or alkalinity of a food, Flavour enhancer - Improves the taste and/or aroma of foods. EAFUS [Everything Added to Food]: A Food Additive Database. Alternate Names: Succinic acid disodium salt; Disodium succinate. It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste. The name derives from Latin succinum, meaning amber. [30] Depending on the cell type, GPR91 can interact with multiple G proteins, including Gs, Gi and Gq, and enabling a multitude of signaling outcomes. [36] Pathologically elevated levels of succinate lead to hypermethylation, epigenetic silencing and changes in neuroendocrine differentiation, potentially driving cancer formation. (405), Propylene glycol esters of fatty acids [39] Other inflammatory cytokines produced by activated macrophages such as tumor necrosis factor or interleukin 6 are not directly affected by succinate and HIF1. View . A Acesulfame potassium (950) Acetic acid, glacial (260) Acetic and fatty acid esters of glycerol (472a) Acetylated distarch adipate (1422) Acetylated distarch phosphate (1414) Acetylated oxidized starch (1451) Acid-treated starch (1401) Adipic acid (355) Advantame (969) Agar (406) Alginic acid (400) Alitame (956) Alkaline treated starch (1402) PubMed online scientific bibliography data. Disodium succinate. A key candidate transporter is INDY (I'm not dead yet), a sodium-independent anion exchanger, which moves both dicarboxylate and citrate into the bloodstream. (160b(ii)), Aspartyl phenylalanine methyl ester* [7], SUCNR1 is one of the highest expressed G protein-coupled receptors on human platelets, present at levels similar to P2Y12, though the role of succinate signaling in platelet aggregation is debated. Hazard statements were adapted to improve readability and may not correspond textually to the hazard statements codes description in the European Union Specific Hazard Statements (EUH) or the.
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